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UBA1 Antibody
As low as
$166.00
In stock
Product Code
CSB-PA00149A0Rb
Product Code:CSB-PA00149A0Rb
Size:50μg/100μg
Host Species:Rabbit
Species reactivity:Human
Test application:ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200
Size:50μg/100μg
Host Species:Rabbit
Species reactivity:Human
Test application:ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200
| Aliases | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1), UBA1, A1S9T UBE1 |
|---|---|
| Target/Protein | UBA1 |
| Uniprot NO. | P22314 |
| Immunogen | Recombinant Human Ubiquitin-like modifier-activating enzyme 1 protein (730-881AA) |
| Host species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Applications | WB, IF, ELISA |
| Background | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). |
| Conjugates | Non-conjugated |
| Form | Liquid |
| Buffer | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Storage | Upon receipt, store at -20 °C or -80 °C. Avoid repeated freeze. |
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