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UBA1 Antibody

As low as $166.00
In stock
Product Code
Product Code:CSB-PA00149A0Rb
Host Species:Rabbit
Species reactivity:Human
Test application:ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200
More Information
Aliases Ubiquitin-like modifier-activating enzyme 1 (EC (Protein A1S9) (Ubiquitin-activating enzyme E1), UBA1, A1S9T UBE1
Target/Protein UBA1
Uniprot NO. P22314
Immunogen Recombinant Human Ubiquitin-like modifier-activating enzyme 1 protein (730-881AA)
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Applications WB, IF, ELISA
Background Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).
Conjugates Non-conjugated
Form Liquid
Buffer Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Storage Upon receipt, store at -20 °C or -80 °C. Avoid repeated freeze.

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