Recombinant Zaire ebolavirus Polymerase cofactor VP35(VP35)

$412.00
In stock
Product Code
CSB-MP764950ZAT
Product Inquiry
Product Code: CSB-MP764950ZAT
Size: 10μg/50μg/100μg/200μg
Species of origin: Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
Application: SDS-PAGE
Express system: Mammalian cell
More Information
Uniprot NO. Q6V1Q9
Target/Protein VP35
Species of origin Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
AA Sequence MTTRTKGRGHTAATTQNDRMPGPELSGWISEQLMTGRIPVSDIFCDIENNPGLCYASQMQQTKPNPKTRNSQTQTDPICNHSFEEVVQTLASLATVVQQQTIASESLEQRITSLENGLKPVYDMAKTISSLNRVCAEMVAKYDLLVMTTGRATATAAATEAYWAEHGQPPPGPSLYEESAIRGKIESRDETVPQSVREAFNNLDSTTSLTEENFGKPDISAKDLRNIMYDHLPGFGTAFHQLVQVICKLGKDSNSLDIIHAEFQASLAEGDSPQCALIQITKRVPIFQDAAPPVIHIRSRGDIPRACQKSLRPVPPSPKIDRGWVCVFQLQDGKTLGLKI
Biologically Active Not Test
Nature Recombinant
Protein description Full Length
MW of Fusion Proten 41.4 kDa
Expression Region 1-340aa
Expression System Mammalian Cell
Purity Greater than 90% as determined by SDS-PAGE.
Application SDS-PAGE
Tag info N-terminal 10xHis-tagged and C-terminal Myc-tagged
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Relevance Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR
Research areas Others

Write Your Own Review
You're reviewing:Recombinant Zaire ebolavirus Polymerase cofactor VP35(VP35)
Your Rating