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Alternative names | CD137;ILA;TNFRSF9;4-1BB ligand receptor;CDw137;T-cell antigen 4-1BB homolog;T-cell antigen ILA |
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Uniprot NO. | Q07011 |
Target/Protein | TNFRSF9 |
Species of origin | Homo sapiens (Human) |
AA Sequence | LQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSPQ |
Activity Data | The ED50 as determined by its ability to bind Human TNFSF9 in functional ELISA is less than 50 ug/ml. |
Protein description | Extracellular Domain |
MW of Fusion Proten | 44 kDa |
Expression Region | 24-186aa |
Expression System | Mammalian Cell |
Purity | Greater than 95% as determined by SDS-PAGE. |
Tag info | C-terminal 6xHis-FC-tagged |
Storage | Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4 |
Relevance | Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. It is absent from naive T cells, but upregulated and continually expressed following T cell activation. It is a receptor for TNFSF9/4-1BBL, and possibly active during T cell activation. |
Research areas | Cancer |