Recombinant Human Tumor necrosis factor(TNF),partial (Active)

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Product Code
CSB-EP023955HUc7
Product Code: CSB-EP023955HUc7
Size: 20μg/100μg/1mg
Species of origin: Homo sapiens (Human)
Express system: E.coli
More Information
Alternative names Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2
Uniprot NO. P01375
Target/Protein TNF
Species of origin Homo sapiens (Human)
AA Sequence E.coli
Activity Data Measured in a cytotoxicity assay using L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 3.065-9.323 ng/mL.
Protein description Partial
MW of Fusion Proten 19.4 kDa
Expression Region 77-233aa
Expression System E.coli
Purity Greater than 85% as determined by SDS-PAGE.
Tag info C-terminal 6xHis-tagged
Storage Tris-based buffer,50% glycerol
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Relevance Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
Research areas Immunology

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