Recombinant Human Tumor Necrosis Factor-alpha/TNFSF2(TNF),partial (Active) (GMP)

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Product Code
Product Code: CSB-AP005891HU
Size: 5μg/100μg/1mg
Species of origin: Homo sapiens (Human)
Express system: E.Coli
More Information
Alternative names Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a
Uniprot NO. P01375
Target/Protein TNF
Species of origin Homo sapiens (Human)
Activity Data Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 0.05 ng/ml, corresponding to a specific activity of > 2.0 Χ 107 IU/mg in the presence of actinomycin D.
Protein description Partial
MW of Fusion Proten 17.5 kDa
Expression Region 77-197aa
Expression System E.coli
Purity > 98 % by SDS-PAGE and HPLC analyses.
Tag info Tag-Free
Storage Lyophilized from a 0.2 λm filtered concentrated solution in 10 mM PB, 10 mM NaCl, pH 7.0.
Relevance Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1, which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line . Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance.
Research areas Cancer

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