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33 kDa housekeeping protein
Peroxin-19
Peroxisomal farnesylated protein
Target/Protein
PEX19
Species of origin
Homo sapiens (Human)
AA Sequence
E.coli
Activity Data
Measured by its binding ability in a functional ELISA. Immobilized ABCD1 at 5 λg/ml can bind human PEX19,the EC50 of human PEX19 protein is 22.96-33.00 λg/ml.
Protein description
Full Length of Mature?Protein
MW of Fusion Proten
59.3 kDa
Expression Region
2-296aa
Expression System
E.coli
Purity
Greater than 90% as determined by SDS-PAGE.
Tag info
N-terminal GST-tagged
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Relevance
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
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Recombinant Human Peroxisomal biogenesis factor 19(PEX19) (Active) Images
