Recombinant Human 5-hydroxytryptamine receptor 1B(HTR1B) (Active) -CUSABIO

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Alternative names	S12 Serotonin 1D beta receptor
Uniprot NO.	,aa_sequenceIn vitro E.coli
Target/Protein	HTR1B
Species of origin	Homo sapiens (Human)
Activity Data	Measured by its binding ability in a functional ELISA. Immobilized HTR1B at 5 λg/ml can bind human GSTK1,the EC50 of human GSTK1 protein is 159.40-218.50 ng/ml.,expression_systemIn vitro E.coli
Protein description	Full Length
MW of Fusion Proten	62.1 kDa
Expression Region	1-390aa
Purity	Greater than 90% as determined by SDS-PAGE.
Tag info	N-terminal 10xHis-SUMO-tagged
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Relevance	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

Recombinant Human 5-hydroxytryptamine receptor 1B(HTR1B) (Active)