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Hepatitis A virus cellular receptor 2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell membrane protein 3; FLJ14428;KIM-3;Tim-3;TIM3;TIMD3
The ED50 as determined by its ability to bind Human Galectin-9 in functional ELISA is less than 20 ug/ml.
Protein description
Partial
MW of Fusion Proten
47.7 kDa
Expression Region
22-200aa
Expression System
Mammalian Cell
Purity
Greater than 90% as determined by SDS-PAGE.
Tag info
C-terminal 6xHis-FC-tagged
Storage
Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
Relevance
Hepatitis A virus cellular receptor 2��HAVCR2��is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
Research areas
Immunology
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Recombinant Human Hepatitis A virus cellular receptor 2(HAVCR2),partial Images
