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Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4(CTLA4),partial

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Product Code
CSB-AP005121GU
Product Code: CSB-AP005121GU
Size: 10μg/50μg/500μg/1mg
Species of origin: Cavia porcellus (Guinea pig)
Express system: Yeast
More Information
Alternative names Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; CTLA4
Uniprot NO. H0VUB1
Target/Protein CTLA4
Species of origin Cavia porcellus (Guinea pig)
AA Sequence AMHVAQPAVVLASSRGVASFECEYASSHNANEVRVTVLQQVASRTTEICAATYTVERELAFPEDSACAGTSSGTRVNLTIQGLRAADTGLYICKVELMYPPPYFVGTGNGTQIYVIDPEPCPDSD
Activity Data The ED50 as determined by its ability to bind Mouse B7-1 in functional ELISA is less than 0.4 ug/ml.
Protein description Partial
MW of Fusion Proten 14.1 kDa
Expression Region 37-161aa
Expression System Yeast
Purity Greater than 90% as determined by SDS-PAGE.
Tag info C-terminal 6xHis-tagged
Storage 0.2 μm Filtered 1xPBS, pH 7.4
Relevance Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
Research areas Immunology

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