Recombinant Human C-C chemokine receptor type 2(CCR2) (Active)

As low as $714.00
In stock
Product Code
CSB-CF004841HU
Product Code: CSB-CF004841HU
Size: 20μg/100μg
Species of origin: Homo sapiens (Human)
Express system: in vitro E.coli expression system
More Information
Alternative names Monocyte chemoattractant protein 1 receptor Short name:MCP-1-R CMKBR2
Uniprot NO. ,aa_sequenceIn vitro E.coli
Target/Protein CCR2
Species of origin Homo sapiens (Human)
AA Sequence MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
Activity Data Measured by its binding ability in a functional ELISA. Immobilized CCR2 at 1 λg/ml can bind human CCL2, the EC50 of human CCL2 protein is 41.51-83.15 λg/ml.,expression_systemIn vitro E.coli
Protein description Full Length
MW of Fusion Proten 45.4 kDa
Expression Region 1-374aa
Expression System In vitro E.coli
Purity Greater than 85% as determined by SDS-PAGE.
Tag info N-terminal 10xHis-tagged
Storage Tris-based buffer,50% glycerol
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Relevance Receptor for the CCL2, CCL7 and CCL13 chemokines. Receptor for the beta-defensin DEFB106A/DEFB106B. Transduces a signal by increasing intracellular calcium ion levels. Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable).
Research areas Cancer

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