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Immobilized Human ACE-2 at 10λg/ml (100 ul/well) can bind 2019-nCoV S Protein RBD-mFc .The ED50 of Recombinant 2019-nCoV S Protein RBD-mFc is 62 ng/ml .
Protein description
Partial
MW of Fusion Proten
84.63 kDa
Expression Region
18-740aa
Expression System
Mammalian Cell
Purity
Greater than 95% as determined by SDS-PAGE.
Tag info
C-terminal 6xHis-tagged
Buffer
0.2 λm Filtered 20 mM Tris, 300 mM NaCl, 1 mM ZnCl2, 10% Glycerol, pH 7.4
Storage
0.2 μm Filtered 20 mM Tris-HCl, 150 mM NaCl, 0.1 mM ZnCl2, 10% Glycerol, pH 7.5
Endotoxin
Less than 1.0 EU/ug as determined by LAL method.
Relevance
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor do not inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
Research areas
Cardiovascular
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Recombinant Human Angiotensin-converting enzyme 2(ACE2),partial Images
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
