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Recombinant Human Angiotensin-converting enzyme 2(ACE2),partial
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$195.00
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Product Code
CSB-AP005671HU
Product Code: CSB-AP005671HU
Size: 10μg/50μg/500μg/1mg
Species of origin: Human
Express system: Mammalian cell
Size: 10μg/50μg/500μg/1mg
Species of origin: Human
Express system: Mammalian cell
| Alternative names | Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2 |
|---|---|
| Uniprot NO. | Q9BYF1 |
| Target/Protein | ACE2 |
| Species of origin | Human |
| AA Sequence | QSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVS |
| Activity Data | Immobilized Human ACE-2 at 10λg/ml (100 ul/well) can bind 2019-nCoV S Protein RBD-mFc .The ED50 of Recombinant 2019-nCoV S Protein RBD-mFc is 62 ng/ml . |
| Protein description | Partial |
| MW of Fusion Proten | 84.63 kDa |
| Expression Region | 18-740aa |
| Expression System | Mammalian Cell |
| Purity | Greater than 95% as determined by SDS-PAGE. |
| Tag info | C-terminal 6xHis-tagged |
| Buffer | 0.2 λm Filtered 20 mM Tris, 300 mM NaCl, 1 mM ZnCl2, 10% Glycerol, pH 7.4 |
| Storage | 0.2 μm Filtered 20 mM Tris-HCl, 150 mM NaCl, 0.1 mM ZnCl2, 10% Glycerol, pH 7.5 |
| Endotoxin | Less than 1.0 EU/ug as determined by LAL method. |
| Relevance | Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor do not inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function. |
| Research areas | Cardiovascular |
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Recombinant Human Angiotensin-converting enzyme 2(ACE2),partial Images
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.