TP53 Antibody

$166.00
In stock
Product Code
CSB-PA07889A0Rb
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Product Code: CSB-PA07889A0Rb
Size: 50μg/100μg
Host Species: Rabbit
Species reactivity: Human|Mouse
Test application: ELISA, WB, IHC, CHIP;Recommended dilution:WB:1:500-1:5000, IHC:1:20-1:200
More Information
Aliases Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53
Alternatives to SCBT sc-1311-R/sc-1314/sc-53396/sc-6243
Target/Protein TP53
Uniprot NO. P04637
Immunogen Recombinant human Cellular tumor antigen p53 protein (2-393AA)
Immunogen Species Human
Host species Rabbit
Species Reactivity Human, Mouse
Clonality Polyclonal
Isotype IgG
Modification unmodified
Applications WB, IHC, ELISA, ChIP
Background Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediatedapoptosis.
Conjugates Non-conjugated
Form Liquid
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Research areas Cell Biology

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