SHFM1 Antibody

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Product Code: CSB-PA021263LA01HU
Size: 50μg/100μg
Host Species: Rabbit
Species reactivity: Human
Test application: ELISA, IHC;Recommended dilution:IHC:1:20-1:200
More Information
Aliases 26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein), SEM1, C7orf76 DSS1 SHFDG1 SHFM1
Alternatives to SCBT sc-28848/sc-5733/sc-5736
Target/Protein SHFM1
Uniprot NO. P60896
Immunogen Recombinant Human 26S proteasome complex subunit SEM1 protein (1-70AA)
Immunogen Species Human
Host species Rabbit
Species Reactivity Human
Clonality Polyclonal
Isotype IgG
Modification unmodified
Applications IHC, ELISA
Background Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in DSS1-depleted cells.
Conjugates Non-conjugated
Form Liquid
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Research areas Cell Biology

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