NP Antibody

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Product Code
CSB-PA325769LA01IIM
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Product Code: CSB-PA325769LA01IIM
Size: 50μg/100μg
Host Species: Rabbit
Species reactivity: Influenza A virus
Test application: ELISA, WB;Recommended dilution:WB:1:500-1:5000
More Information
Aliases Nucleoprotein (Nucleocapsid protein) (Protein N)
Alternatives to SCBT N/A
Target/Protein NP
Uniprot NO. P15682
Immunogen Recombinant Influenza A virus Nucleoprotein protein (1-498AA)
Immunogen Species Influenza A virus
Host species Rabbit
Species Reactivity Influenza A virus
Clonality Polyclonal
Isotype IgG
Modification unmodified
Applications WB, ELISA
Background Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus (By similarity).
Conjugates Non-conjugated
Form Liquid
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Research areas Others

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