N Antibody

$166.00
In stock
Product Code
CSB-PA318492LA01JAM
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Product Code: CSB-PA318492LA01JAM
Size: 50μg/100μg
Host Species: Rabbit
Species reactivity: Junin mammarenavirus
Test application: ELISA, WB;Recommended dilution:WB:1:500-1:5000
More Information
Aliases Nucleoprotein (Nucleocapsid protein) (Protein N)
Alternatives to SCBT N/A
Target/Protein N
Uniprot NO. P14239
Immunogen Recombinant Junin mammarenavirus Nucleoprotein protein (1-564AA)
Immunogen Species Junin mammarenavirus
Host species Rabbit
Species Reactivity Junin mammarenavirus
Clonality Polyclonal
Isotype IgG
Modification unmodified
Applications WB, ELISA
Background Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity). Interacts with host IKBKE (via Protein kinase domain); the interaction inhibits IKBKE kinase activity.
Conjugates Non-conjugated
Form Liquid
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Research areas Others

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