LMP2 Antibody

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Product Code: CSB-PA321086HA01EFA
Size: 50μg/100μg
Host Species: Rabbit
Species reactivity: Epstein-Barr virus
Test application: ELISA, WB;Recommended dilution:WB:1:200-1:2000
More Information
Aliases Latent membrane protein 2 (Terminal protein)
Alternatives to SCBT N/A
Target/Protein LMP2
Uniprot NO. P13285
Immunogen Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA)
Immunogen Species Epstein-Barr virus
Host species Rabbit
Species Reactivity Epstein-Barr virus
Clonality Polyclonal
Isotype IgG
Modification unmodified
Applications WB, ELISA
Background Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.
Conjugates Non-conjugated
Form Liquid
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Research areas Others

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