L1 Antibody

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Product Code:L1 Antibody
Host Species:Rabbit
Species reactivity:Human papillomavirus type 18
Test application:ELISA, WB; Recommended dilution: WB:1:1000-1:5000
More Information
Aliases Major capsid protein L1
Alternatives to SCBT N/A
Target/Protein L1
Uniprot NO. P06794
Immunogen Recombinant HPV18 Major capsid protein L1 protein (1-568AA)
Immunogen Species Human papillomavirus type 18
Host species Rabbit
Species Reactivity Human papillomavirus type 18
Clonality Polyclonal
Isotype IgG
Modification unmodified
Applications WB, ELISA
Background Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on the basement membrane to provide initial virion attachment to target cells. Basement membrane is exposed only after epithelium trauma. Additionally, the alpha6 integrin complexed with either beta1 or beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, integrin complexed with beta4 integrin has been proposed to act as a coreceptor recognized by L1. Once attached, the virion enters the host cell via clathrin-mediated endocytosis and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
Conjugates Non-conjugated
Form Liquid
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Research areas Microbiology

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