IFNL3 Antibody

As low as $166.00
In stock
Product Code
CSB-PA810313ESR1HU
Product Code:IFNL3 Antibody
Size:50μg/100μg
Host Species:Rabbit
Species reactivity:Human
Test application:ELISA, IHC; Recommended dilution: IHC:1:20-1:200
More Information
Aliases Interferon lambda-3 (IFN-lambda-3) (Cytokine Zcyto22) (Interleukin-28B) (IL-28B) (Interleukin-28C) (IL-28C), IFNL3
Alternatives to SCBT N/A
Target/Protein IFNL3
Uniprot NO. Q8IZI9
Immunogen Recombinant Human Interferon lambda-3 protein (22-196AA)
Immunogen Species Human
Host species Rabbit
Species Reactivity Human
Clonality Polyclonal
Isotype IgG
Modification unmodified
Applications IHC, ELISA
Background Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Conjugates Non-conjugated
Form Liquid
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Research areas Immunology

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