Hp Antibody

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Product Code
CSB-PA17069A0Rb
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Product Code:Hp Antibody
Size:50μg/100μg
Host Species:Rabbit
Species reactivity:Mouse|Rat
Test application:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200
More Information
Aliases Haptoglobin (Liver regeneration-related protein LRRG173) (Zonulin) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain]
Alternatives to SCBT N/A
Target/Protein Hp
Uniprot NO. P06866
Immunogen Recombinant Rat Haptoglobin protein (19-346AA)
Immunogen Species Rat
Host species Rabbit
Species Reactivity Mouse, Rat
Clonality Polyclonal
Isotype IgG
Modification unmodified
Applications WB, IHC, ELISA
Background As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway?.Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
Conjugates Non-conjugated
Form Liquid
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Research areas Cardiovascular

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