HDAC3 Antibody

$166.00
In stock
Product Code
CSB-PA010239LA01HU
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Product Code: CSB-PA010239LA01HU
Size: 50μg/100μg
Host Species: Rabbit
Species reactivity: Human|Mouse
Test application: ELISA, WB, IHC, IF, ChIP;Recommended dilution:WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200
More Information
Aliases HD3, RPD3-2, SMAP45, HDAC3
Alternatives to SCBT sc-8138
Target/Protein HDAC3
Uniprot NO. O15379
Immunogen Recombinant human Histone deacetylase 3 protein (1-428AA)
Immunogen Species Human
Host species Rabbit
Species Reactivity Human, Mouse
Clonality Polyclonal
Isotype IgG
Modification unmodified
Applications WB, IHC, IF, ELISA, ChIP
Background Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.
Conjugates Non-conjugated
Form Liquid
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Research areas Epigenetics and Nuclear Signaling

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