GAPDH Antibody

$166.00
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Product Code
CSB-PA009232HA01DXU
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Product Code: CSB-PA009232HA01DXU
Size: 50μg/100μg
Host Species: Rabbit
Species reactivity: Cricetulus griseus
Test application: ELISA, WB;Recommended dilution:WB:1:500-1:5000
More Information
Aliases Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-), GAPDH
Alternatives to SCBT N/A
Target/Protein GAPDH
Uniprot NO. P17244
Immunogen Recombinant Cricetulus griseus Glyceraldehyde-3-phosphate dehydrogenase protein (2-333AA)
Immunogen Species Cricetulus griseus
Host species Rabbit
Species Reactivity Cricetulus griseus
Clonality Polyclonal
Isotype IgG
Modification unmodified
Applications WB, ELISA
Background Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (By similarity).
Conjugates Non-conjugated
Form Liquid
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Research areas Others

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