* Online payment is not available now. Please send your PO to firstname.lastname@example.org. We will deal with it soon. * The information on this page is not updated. For the latest product information, please search on cusabio.com with the product code.
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Write Your Own Review
CLU Antibody Images
All lanes: Clusterin antibody at 2ug/ml+293T whole cell lysate
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 53, 58, 33, 49, 54 kDa
Observed band size: 49 kDa
Immunofluorescence staining of Hela cells with CSB-PA06029A0Rb at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated w
Immunohistochemistry of paraffin-embeded human prostate using CSB-PA06029A0Rb at dilution of 1:100
IHC image of CSB-PA06029A0Rb diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Se
IHC image of CSB-PA06029A0Rb diluted at 1:200 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section