BUB1B Antibody

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Product Code
Product Code:BUB1B Antibody
Host Species:Rabbit
Species reactivity:Human
Test application:ELISA, IHC, IF, IP; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500, IP:1:200-1:2000
More Information
Aliases Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1), BUB1B
Alternatives to SCBT sc-130708/sc-16193/sc-16195
Target/Protein BUB1B
Uniprot NO. O60566
Immunogen Recombinant Human Mitotic checkpoint serine/threonine-protein kinase BUB1 beta protein (230-394AA)
Immunogen Species Human
Host species Rabbit
Species Reactivity Human
Clonality Polyclonal
Isotype IgG
Modification unmodified
Applications IHC, IF, ELISA, IP
Background Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
Conjugates Non-conjugated
Form Liquid
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Research areas Cell Biology

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