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Aliases | Angiopoietin-2 (ANG-2), Angpt2 |
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Alternatives to SCBT | N/A |
Target/Protein | Angpt2 |
Uniprot NO. | O35608 |
Immunogen | Recombinant Mouse Angiopoietin-2 protein (19-483AA) |
Immunogen Species | Mouse |
Host species | Rabbit |
Species Reactivity | Mouse |
Clonality | Polyclonal |
Isotype | IgG |
Modification | unmodified |
Applications | WB, IHC, ELISA |
Background | Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal |
Conjugates | Non-conjugated |
Form | Liquid |
Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Research areas | Cardiovascular |