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A synthesized peptide derived from human Phospho-ERN1 (S724)
Clonality
Monoclonal
Applications
WB, IF, ELISA
Background
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:9637683, PubMed:11175748, PubMed:12637535). The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis (PubMed:24508390).
Conjugates
Non-conjugated
Form
Liquid
Buffer
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage
Upon receipt, store at -20 °C or -80 °C. Avoid repeated freeze.
