Phospho-CBL (Tyr700) Antibody

As low as $360.00
In stock
Product Code
Product Code:CSB-PA205538
Size: 100ul
Host Species:Rabbit
Species reactivity:Human
Test application:ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200
More Information
Aliases Signal transduction protein CBL; Proto-oncogene c-CBL; Casitas B-lineage lymphoma proto-oncogene; RING finger protein 55;
Target/Protein Phospho-CBL
Uniprot NO. P22681
Immunogen Peptide sequence around phosphorylation site of tyrosine 770 (T-E-Y(p)-M-T) derived from Human c-Cbl.
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Applications WB, IHC, IF, ELISA
Background Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.<br/><br/>Blake, T.J. et al. (1991) Oncogene 6, 653-657.<br/>Thien, C.B. and Langdon, W.Y. (1998) Immunol. Cell Biol. 76, 473-482.<br/>Kamei, T. et al. (2000) Int. J. Oncol. 17, 335-339.<br/>Hunter, C. et al. (1999) J. Biol. Chem. 274, 2097-2106.<br/>
Conjugates Non-conjugated
Form liquid
Buffer Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Upon receipt, store at -20 °C or -80 °C. Avoid repeated freeze.

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