Phospho-CBL (Tyr674) Antibody

As low as $360.00
In stock
Product Code
CSB-PA574497
Product Code:CSB-PA574497
Size: 100ul
Host Species:Rabbit
Species reactivity:Human, Mouse, Rat
Test application:ELISA, WB;WB:1:500-1:1000
More Information
Aliases C-CBL; CBL2; Proto-oncogene c-Cbl; RNF55;
Target/Protein Phospho-CBL
Uniprot NO. P22681
Immunogen Peptide sequence around phosphorylation site of Tyrosine674 (A-I-Y(p)-S-L) derived from Human CBL.
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Applications WB, ELISA
Background <p>Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.<br/><br/>Fernandes MS, et al. (2010) J Biol Chem 285, 32596-605 <br />Teckchandani AM, Panetti TS, Tsygankov AY (2005) Exp Cell Res 307, 247-58 </p>
Conjugates Non-conjugated
Form liquid
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Upon receipt, store at -20 °C or -80 °C. Avoid repeated freeze.

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