NTRK1 Antibody

As low as $210.00
In stock
Product Code
CSB-RA202683A0HU
Product Code:CSB-RA202683A0HU
Size:50μl/100μl
Host Species:
Species reactivity:Human, Mouse, Rat
Test application:ELISA, WB; Recommended dilution: WB:1:500-1:5000
More Information
Aliases High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA), NTRK1, MTC TRK TRKA
Target/Protein NTRK1
Uniprot NO. P04629
Immunogen A synthesized peptide derived from human TrkA
Clonality Monoclonal
Applications WB, ELISA
Background Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:17196528). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.
Conjugates Non-conjugated
Form Liquid
Buffer Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Upon receipt, store at -20 °C or -80 °C. Avoid repeated freeze.

Write Your Own Review
You're reviewing:NTRK1 Antibody
Your Rating