N Polyclonal Antibody- CUSABIO

More Information
Aliases	Nucleoprotein (Nucleocapsid protein) (Protein N), N
Alternatives to SCBT	N/A
Target/Protein	N
Uniprot NO.	P14239
Immunogen	Recombinant Junin mammarenavirus Nucleoprotein protein (1-564AA)
Immunogen Species	Junin mammarenavirus
Host species	Rabbit
Species Reactivity	Junin mammarenavirus
Clonality	Polyclonal
Isotype	IgG
Modification	unmodified
Applications	WB, ELISA
Background	Encapsidates the genome,protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE,strongly inhibits the phosphorylation and nuclear translocation of IRF3,a protein involved in IFN activation pathway,leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity). Interacts with host IKBKE (via Protein kinase domain); the interaction inhibits IKBKE kinase activity.
Conjugates	Non-conjugated
Form	Liquid
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Research areas	Others

N Antibody