LCN2 Monoclonal Antibody

$210.00
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Product Code
CSB-MA068302A0m
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Product Code:CSB-MA068302A0m
Size:50μg/100μg
Host Species:Mouse
Species reactivity:Human|Mouse
Test application:ELISA, WB, IHC;Recommended dilution:WB:1:500-1:5000, IHC:1:50-1:500
More Information
Aliases 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; p25; LCN2; HNL; NGAL
Alternatives to SCBT sc-57517/sc-57518/sc-59622
Target/Protein LCN2
Uniprot NO. P80188
Immunogen Recombinant Human Neutrophil gelatinase-associated lipocalin protein
Immunogen Species Human
Host species Mouse
Species Reactivity Human, Mouse
Clonality Monoclonal
Isotype IgG2b
Modification unmodified
Applications WB, IHC, ELISA
Background Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2, 5-dihydroxybenzoic acid (2, 5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Conjugates Non-conjugated
Form liquid
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Research areas Immunology

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