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Aliases | Insulin-like growth factor I receptor; CD221; IGF1R; kinase IGF1R; |
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Target/Protein | IGF1R |
Uniprot NO. | P08069 |
Immunogen | Peptide sequence around aa.1159~1163 (D-I-Y-E-T) derived from Human IGF-1R . |
Host species | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Applications | WB, IHC, IF, ELISA |
Background | This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.<br/><br/>Li S, et al. (1994) J Biol Chem; 269(51). <br/>Hernandez-Sanchez C, et al. (1995) J Biol Chem. <br/> |
Conjugates | Non-conjugated |
Form | liquid |
Buffer | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Storage | Upon receipt, store at -20 °C or -80 °C. Avoid repeated freeze. |