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ERBB2 Antibody
As low as
$210.00
In stock
Product Code
CSB-RA260392A0HU
Product Code:CSB-RA260392A0HU
Size:50μl/100μl
Host Species:
Species reactivity:Human
Test application:ELISA, IHC, IF; Recommended dilution: IHC:1:50-1:200, IF:1:20-1:200
Size:50μl/100μl
Host Species:
Species reactivity:Human
Test application:ELISA, IHC, IF; Recommended dilution: IHC:1:50-1:200, IF:1:20-1:200
| Aliases | Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340), ERBB2, HER2 MLN19 NEU NGL |
|---|---|
| Target/Protein | ERBB2 |
| Uniprot NO. | P04626 |
| Immunogen | A synthesized peptide derived from human ErbB2 (HER2) |
| Clonality | Monoclonal |
| Applications | IHC, IF, ELISA |
| Background | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. |
| Conjugates | Non-conjugated |
| Form | Liquid |
| Buffer | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage | Upon receipt, store at -20 °C or -80 °C. Avoid repeated freeze. |
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